Computational morphometry in schizophrenia and related disorders

With this project we want to develop, evaluate and apply novel computational tools for the purpose of understanding morphometric changes in neuroanatomical structures related to schizophrenia. Shape measures are of interest in schizophrenia because this disorder is viewed by some as a neurodevelopmental in origin and because there is evidence to suggest that during morphogenesis of the brain, abnormal pressures and/or tissue formations likely change the shape of brain structures, particularly those in the midline of the brain, as well as influencing folding patterns of the neocortex. We believe that computational morphometry tools are critical to characterize and to quantify shape changes accurately. In fact, neuroscience research as a whole has shown a growing interest in computer assisted shape studies for numerous conditions including, but not limited to, normal neurodevelopment, Alzheimer's disease, schizophrenia and schizotypal personality disorder (SPD), bipolar disorder, psychotic affective disorder, and fetal alcohol exposure.

Carl-Fredrik Westin

Dr. Carl-Fredrik Westin

Director, Laboratory for Mathematics in Imaging
Professor of Radiology, Harvard Medical School

Carl-Fredrik (C-F) Westin is the founding director of the Laboratory of Mathematics in Imaging (LMI, http:// lmi.med.harvard.edu), and he is Professor of… Read more about Carl-Fredrik Westin

Harvard Medical School, Brigham and Women's Hospital
Department of Radiology, 1249 Boylston Street, Boston, MA 02215
p: (+1) 617-525-6209