Computational morphometry in schizophrenia and related disorders

With this project we want to develop, evaluate and apply novel computational tools for the purpose of understanding morphometric changes in neuroanatomical structures related to schizophrenia. Shape measures are of interest in schizophrenia because this disorder is viewed by some as a neurodevelopmental in origin and because there is evidence to suggest that during morphogenesis of the brain, abnormal pressures and/or tissue formations likely change the shape of brain structures, particularly those in the midline of the brain, as well as influencing folding patterns of the neocortex. We believe that computational morphometry tools are critical to characterize and to quantify shape changes accurately. In fact, neuroscience research as a whole has shown a growing interest in computer assisted shape studies for numerous conditions including, but not limited to, normal neurodevelopment, Alzheimer's disease, schizophrenia and schizotypal personality disorder (SPD), bipolar disorder, psychotic affective disorder, and fetal alcohol exposure.

Martha E Shenton

Dr. Martha E Shenton

Professor, Departments of Psychiatry and Radiology, Brigham and Women’s Hospital, Harvard Medical School

The broad goal of Dr. Shenton’s research program (see http://pnl.bwh.harvard.edu) has been to apply new imaging techniques to the study of

Read more about Martha E Shenton
Brigham and Women's Hospital
Department of Psychiatry & Radiology
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