NIH U01NS083223 (Diffusion MRI in Huntington's)

Wassermann D, Makris N, Rathi Y, Shenton M, Kikinis R, Kubicki M, Westin C-F. The white matter query language: a novel approach for describing human white matter anatomy. Brain Struct Funct. 2016.Abstract
We have developed a novel method to describe human white matter anatomy using an approach that is both intuitive and simple to use, and which automatically extracts white matter tracts from diffusion MRI volumes. Further, our method simplifies the quantification and statistical analysis of white matter tracts on large diffusion MRI databases. This work reflects the careful syntactical definition of major white matter fiber tracts in the human brain based on a neuroanatomist's expert knowledge. The framework is based on a novel query language with a near-to-English textual syntax. This query language makes it possible to construct a dictionary of anatomical definitions that describe white matter tracts. The definitions include adjacent gray and white matter regions, and rules for spatial relations. This novel method makes it possible to automatically label white matter anatomy across subjects. After describing this method, we provide an example of its implementation where we encode anatomical knowledge in human white matter for ten association and 15 projection tracts per hemisphere, along with seven commissural tracts. Importantly, this novel method is comparable in accuracy to manual labeling. Finally, we present results applying this method to create a white matter atlas from 77 healthy subjects, and we use this atlas in a small proof-of-concept study to detect changes in association tracts that characterize schizophrenia.
Demian Wassermann

Dr. Demian Wassermann

research associate (chargé de recherche) at the Athena team, INRIA Sophia Antipolis-Méditerranée.

LMI: 2010 - 2013

My work mainly focuses on developing mathematical models of brain anatomy, through Diffusion MRI and their… Read more about Demian Wassermann

2004 route des Lucioles, 06902, Sophia-Antipolis CEDEX, France
Carl-Fredrik Westin

Dr. Carl-Fredrik Westin

Director, Laboratory for Mathematics in Imaging
Professor of Radiology, Harvard Medical School

Carl-Fredrik (C-F) Westin is the founding director of the Laboratory of Mathematics in Imaging (LMI, http:// lmi.med.harvard.edu), and he is Professor of… Read more about Carl-Fredrik Westin

Harvard Medical School, Brigham and Women's Hospital
Department of Radiology, 1249 Boylston Street, Boston, MA 02215
p: (+1) 617-525-6209